|
KMID : 0613820210310060550
|
|
Journal of Life Science
2021 Volume.31 No. 6 p.550 ~ p.558
|
|
|
Extract of Fructus Corni Ameliorates Testosterone-induced Benign Prostatic Hypertrophy in Sprague Dawley Rats
|
|
Ji Seon-Yeong
Kim Min-Yeong
Hwangbo Hyun
Lee Hye-Sook
Hong Su-Hyun
Kim Tae-Hee
Yoon Seon-Hye
Kim Hyun-Jin
Kim Sung-Yeon
Jung Ha-Eun
Kim Tae-Jung
Kim Min-Ji
Kim Sung-Ok
Choi Yung-Hyun
|
|
|
Abstract
|
|
|
|
Fructus Corni, the fruit of Cornus officinalis, has long been used for the prevention and treatment of various diseases. We recently suggested that it was effective against benign prostatic hyperplasia (BPH). In this study, we investigated the inhibitory effect of Corni Fructus (CF) water extract on BPH induced by testosterone propionate (TP) in noncastrated and castrated animal models. BPH was induced in Sprague Dawley rats by an intramuscular injection of TP in castrated or noncastrated rats. Finasteride (FINA) treatment was used as a positive control for inhibition of BPH. According to our results, CF administration inhibited excessive enlargement of development of the prostate in both the noncastrated and castrated groups compared to the control and FINA-treated groups. The inhibitory effect of CF on BPH was associated with inhibition of expression of hypoxia-inducible factor-1α, 5α-reductase type 2, steroid receptor coactivator-1, androgen receptor (AR), and prostate-specific antigen. Serum levels of the stress hormone cortisol increased during BPH induction by TP in both the noncastrated and castrated groups, but they were attenuated significantly by CF administration. However, insulin and IGF-1 levels were not increased in the BPH-induced groups and CF, and no effective results were found by CF administration. These results point to a beneficial effect of CF on BPH through inhibition of AR signaling pathway activity and imply that CF shows excellent potential as a therapeutic agent for the prevention and treatment of BPH.
|
|
|
KEYWORD
|
|
|
Androgen receptor, benign prostatic hyperplasia, Corni Fructus, cortisol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|